Endocrine Abstracts

Introduction: Acromegaly is a chronic endocrine disorder caused by excess growth hormone (GH) secretion. Hypersecretion of GH causes increased IGF-1 secretion from the liver which in turn leads to a series of multisystemic complications including somatic overgrowth and multiple comorbidities.Case report: Thirty-nine-year-old female patient was seen in ophthalmology outpatient clinic with the complaint of a mass inside the right upper eyelid. On ophthalmo...

An empty sella (ES) develops when cerebrospinal fluid (CSF) compresses pituitary tissue until it lines the sellar floor and walls and lead to shrinkage of pituitary gland. Primary ES occurs when CSF enters the sella from the subarachnoid space that may or may not be associated with increased intracranial pressure. Secondary ES is a result of an injury to the pituitary itself (e.g. pituitary apoplexy) or the consequence of surgical or radiation treatment. Primary ES is most com...

A 22-year-old man presented to the Endocrinology unit for short stature. His height is 1.53 cm; weight is 38.5 kg. Physical examination revealed short stature, lean body mass, low-set ears and a short fifth finger on the right. His bone age were consistent with 19-year. He had a history of undescended testis operation at 5-year old and history of strabismus surgery at 14-year old. He had a delta f 508 heterozygote mutation with normal sweat test. His biochemical analysis excep...

Blood flow obstruction through superior vena cava leads to superior vena cava syndrome (VCSS). The most common cause of the VCSS is malignancies. Enlargement goitre is an unusual cause of VSSS. A patient with superior vena cava syndrome secondary to enlarged thyroid gland was presented in this case report. An 84-year-old man presented to endocrinology unit with gradually increasing neck mass, dysphagia, and shortness of breath. His physical examination revealed webbed neck wit...

Mitogen-activated protein kinases (MAPK) are a family of serine/threonine kinases and are key signaling pathways involved in the regulation of normal cell proliferation, survival and differentiation. In mammals, there are more than a dozen MAPK genes. The best known are the extracellular signal-regulated protein kinases (ERK1 and 2); c-Jun N-terminal kinases (JNK1-3); p38s (α, β, γ, δ) and ERK5. Aberrant regulation of MAPK cascades contribute to cancer and ...

A 71-year-old hypertensive and diabetic male patient was seen in the outpatient clinic for routine control. On laboratory examination his serum potassium level was 5.76 mmol/l and serum sodium level was 135 mmol/l. Control serum potassium level was 5.7 mmol/l. In past medical history he was prescribed telmisartan/hydrochlorothiazide combination (80 mg/12.5 mg) 1 month ago for treatment of hypertension. His other medications included nifedipine, fluvastatin sodium, aspirin, pio...

A 17-year-old girl was referred to Endocrinology Unit by her neurosurgeon. She had complained of severe headache, palpation induced galactorrhoea on left mammary and visual abnormalities for 1–2 months. Her menstrual period was regular. On physical examination a pale face and fatigued appearance was noticed. Biochemical and hormonal analyses are as follows: fasting glucose level was 84 mg/dl, serum sodium level was 140 mmol/l (136–145), serum potassium level was 3.9 ...

Aim: The aim of the study was to determine the association between Hashimoto’s thyroiditis (HT) and differentiated thyroid carcinoma (DTC).Patients and methods: Seven hundred seventy two patients with thyroid nodular goiter who underwent fine-needle aspiration cytology (FNAC), followed up at Endocrinology and Metabolism out-patient clinic of Cerrahpasa Medical School, University of Istanbul between January 2000 and December 2010 were included retros...

Introduction: The aldosterone-to-renin ratio (A/R) is the most frequently used screening test for primary hyperaldosteronism (PH) and a confirmation test is recommended when it is high. We aimed to determine the frequency of PH in patients with high A/R and investigated possible clinical features that might help to prevent unnecesary confirmation tests.Method: Patients who underwent saline infusion test because of high A/R (>3.8) were retrospectively...

Introduction: Subacute thyroiditis is an iflammatory disease of the thyroid gland characterized by pain, tenderness and swelling in the neck. Less frequently, it may present with painless or silent thyroiditis that occurs spontaneously or in the postpartum period. In a few studies in the literature, urinary iodine was reported to be high in patients with postpartum thyroiditis, but it was not evaluated in patients with subacute thyroiditis. We aimed to evaluate urinary iodine ...